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A topical copper peptide serum concentrates the active complex at the tissue where its collagen-stimulating and anti-inflammatory effects are most relevant

J.HarrisonS

reported that TQ at 80 mg/kg, but not 40 mg/kg, markedly caused chromosomal aberrations and DNA damage in the liver and kidney of BALB/c mice, indicating its genotoxic risk at high doses [331]

PubMed Central , Complementary Therapies in Medicine , vol

Historically, hydroquinone (HQ) 4% as monotherapy, but also in combination with tretinoin and topical steroids (triple cream), has been an established topical, first-line treatment over years, but concerns about its side effects (permanent depigmentation, ochronosis, potential risk of cancer due to its metabolites) have prompted the use of potentially safer alternatives and the withdrawal of HQ in many countries

Research models show the combined GHRH+GHRP mechanism produces a synergistic GH pulse that neither molecule produces alone