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Propionate mitochondrial toxicity in liver and skeletal muscle: Acyl CoA levels

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When ingested, stomach acids often break down these forms of glutathione before they can be fully absorbed by the body

Physiol Rev 94:739777 Last K, Maharaj L, Perry J, Strauss S, Fitzgibbon J, Lister TA, Joel S (2006) The activity of methylated and non-methylated selenium species in lymphoma cell lines and primary tumours

In principle, a hyperoxidizing ER might simply blunt the UPR rather than improve ER function, because activation of at least the UPR sensors ATF6 and IRE1 can be inhibited by oxidation (Nadanaka et al., 2007, Wang et al., 2018)

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