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In conclusion, our non-targeted metabolomics approach identified several molecules, such as carnitine derivatives, and antioxidant agents, such as taurine and glutathione

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Owing to the lack of a higher-order chromatin structure, free peptides fail to reflect enzymatic kinetic characteristics accurately, whereas the catalytic efficiency of HDAC/sirtuin is more accurately assessed when using nucleosome substrates [42]

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It has been suggested that glutamate could be synthesised through the action of glutamate dehydrogenase on cellular -ketoglutarate, recycling the ammonia produced by glutaminase activity and reducing NAD + in the process (Fig

Figure 2 6 Metabolic cross-talk between N