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Kamermans, A

They were combined at a very high temperature and shown to form nicotinic acid, which can lead to skin irritation, says Singh

Farook MR, Croxford Z, Morgan S, Horlock AD, Holt AK, Rees A, et al

Int J Mol Sci 21(4):1410

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While CD19-directed CAR T-cell therapies revolutionized treatment of hematological malignancies (123), translating this success to solid tumors, and especially into the CNS, has posed more of a challenge due to antigen heterogeneity, the immunosuppressive TME, and the restrictive BBB