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The residues lining the binding pocket of human FLVCR2 are hydrophobic at the top (Trp102, Ile226, and Phe324) and mostly polar at the bottom and the sides (Ser99, Gln191, Asn222, Tyr325, Gln447)

SNP rs5770917 adjacent to the gene encoding CPT1B has been found to be associated with narcolepsy [16]

Moreover, intranasal applications achieved higher, longer-lasting brain drug concentrations compared to intravenous administration [81, 87]

In addition, TGF- suppresses the activity of ATP synthase in effector memory CD4 + T cells and therefore reduces mitochondria respiratory capacity (Mills et al., 2017), these inhibitory effects on OXPHOS in immune cells may underlie some negative effects of TGF- in immunity

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