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While -synuclein (-Syn), which is encoded by SNCA , is one of the fundamental components in the Lewy body, patients with SNCA mutants (A30P, E46K, H50Q, G51D, A53E, and A53T) or multiplications are really rare, characterized by autosomal dominant inheritance, widely distributed age of onset (from 19 to 81 years), and more rapid cognitive impairment (Rosborough et al., 2017)

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Discoloration changes indicate degradation: Cloudiness = peptide precipitation or contamination Green or pink discoloration = copper reduction (Cu Cu) Colorless = complete copper dissociation Reconstituted solutions should be stored at 28 C

However, several indirect mechanisms may influence B12 levels in patients using these treatments

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The SFG interferogram was then dispersed into a spectrometer (Shamrock 303i, Andor Technology) and detected by a charge-coupled device camera (Newton, Andor Technology)