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Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterise their transcriptome disturbances

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An exemplary case of MRTX849, a covalent inhibitor targeting KRAS G12C mutant, benefited from a lower reactivity warhead with an additional fluorine at the acrylamide -carbon position, thus achieving better metabolic stability [113]

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Records that met the inclusion criteria proceeded to a second round, during which full-text screening was conducted by the same reviewers