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sulindac, a NSAID, which inhibits COX-2 [54] and the anti-diabetic drug pioglitazone, which is an agonist of the peroxisome proliferator-activated receptor gamma with anti-inflammatory effects [55, 56]

10.1080/2162402X.2017.1316437 249 SerZ.GaoX.JohnsonC.MehrmohamadiM.LiuX.LiS.et al

Priorities for research include head-to-head evaluation of analogs in EMS models with integrated pharmacokineticpharmacodynamic mapping and iterative chemistry to lower promiscuous binding without compromising on-lesion potency