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The comparison groups should match the new treatment group in average age, gender distribution, diagnosis, level of functioning, and any other potentially confounding variables

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Alison Champagne: nothing to disclose

Methods: Prospective single-centre study of 108 patients presenting with acute, severe proximal LVO with a complete neuroimaging study (CT at baseline and follow-up MRI) and blood tests including serum ALCAM measured at 24 and 48 +/- 12 hours