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During lipid peroxidation, cyclic guanosine monophosphate (cGMP) is elevated, along with the downregulation of cyclic adenosine monophosphate (cAMP) concentration, leading to accelerated proliferation of epidermal cells in psoriasis ( Extensive experiments are proving that various subsets of T cells, including Th1, Th2, Th17, and regulatory T cells (Treg cell), as well as related cytokines, such as TNF-, IFN-, IL-23, and IL-17, engage in the pathogenesis of psoriasis (Soler et al., 2013

Carica papaya extract stimulates Nrf2 in a mechanism that depends on the interaction of the Carica papaya flavonoids with the Nrf2 binding pocket of keap-1, leading to release of Nrf2 and its nuclear accumulation (Kumar et al., 2024)

Glutathione acts as a primary defender against oxidative stress

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Chelation therapy is most commonly used for heavy metal toxicity, including lead, mercury, aluminum, cadmium, gadolinium, and arsenic

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