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doi: 10.1136/gutjnl-2020-322429 102

on inhibition of proliferation, apoptosis induction and NF-B signaling of immortalized and cancer cell lines

Mtb infection is also known to significantly reduce the intracellular level of GSH in macrophages (158)

The H -score ranged from 0-300 and the optimal cutoff value for it was defined via the largest Youden index under the receiver operating characteristic (ROC) ( Cell Culture PC cell lines (MIA PaCa-2, PANC-1, CFPAC-1, T3M4, BxPC-3, and AsPC-1) were obtained from the American Type Culture Collection (Virginia, USA)

Has been shown to inhibit NF-B, possibly through inhibition of JNK (IC 50 =10M), the COP9 signalosome kinase (IC 50 =10M) and p300/CBP

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