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PKM2 can be transferred to the nucleus and form a complex with transforming growth factor signaling inhibitory factor TGF-induced factor (TGIF2) and histone deacetylase 3 (HDAC3), and this complex will bind to the cadherin1 (CDH1) promoter and deacetylate it, thereby inhibiting the expression of e-cadherin, so that epithelial cells will lose their mediated cell adhesion and become invasive

While CHAC1 is limited to higher eukaryotes, CHAC2 is present across a broad phylogenetic range

It should be noted that the human brain with its multimodal structure has undergone dramatic changes in brain regions such as the frontal and temporal lobes during evolution

It comes with risks, costs, and recovery time

The problem is not in the production of leptin

however, the exact underlying mechanism remains unclear