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4 shows the position of the choline group on phosphatidylcholine

It is widely believed that the daily consumption of more than 50 grams of alcohol has a high likelihood of worsening the fibrosis, but there are reports of levels of alcohol intake of less than that amount having a deleterious effect on the liver disease207

In this study, it was observed that the protective effect of spermidine seems to be associated with a modulation of gut microbiota composition into a more anti-inflammatory one, as well as in the increment of Desulfovibrionacea species that can improve polyamine metabolism and promote a more resilient intestinal barrier (111, 112)