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found that O-GlcNAcylated c-Jun stimulated GSH synthesis via increasing PSAT1 and CBS transcription to inhibit ferroptosis in HCC cells (Harvey et al., 2013)

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GSH / GSSG balance is crucial for homeostasis, stabilizing cellular biomolecular spectrum, and facilitating cellular performance and survival

NACET is generally well-tolerated

Knockdown of SQLE significantly increased the sensitivity of OC cells to ferroptosis inducers, such as GPX4 inhibitors, and markedly inhibited tumor growth in in vivo experiments (138)