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doi: 10.3389/fmicb.2018.00291 18 Da SilveiraM

This was supported by the findings that elevated steady-state ROS levels in neoplastic cells make them more vulnerable to oxidative stress than normal cells [46], and that apoptotic cell death in malignant cells linked with conventional anti-cancer chemotherapy is exacted partly through inducing ROS production [47], noting side effects on normal tissues [48]

If your heart rate is increased to compensate for the lowered amount of blood your heart is receiving, then lowering it will reduce the volume of blood its pumping out