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They secrete a spectrum of profibrotic mediators, including TGF-1, IL-10, arginase-1, and CCL18, which promote fibroblast proliferation, myofibroblast differentiation, and excessive ECM deposition (109)

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thus, greater than 260 per 10,0000 military service members experience subsequent head injury within 1 year of an initial TBI (7)

Oxidative burst is quantitively indicated by increase in NOX-dependent oxygen consumption rate, which peaks around 30 min after stimulation by zymosan, PMA or TNF- (Fig