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Only active ingredients supported by published clinical trial data demonstrating significant improvement in hyperpigmentation (measured by validated clinical scores, colorimetry, or imaging) compared to vehicle or baseline are included in this review

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Sigma Aldrich) and Complete Protease Inhibitor Cocktail (Roche Diagnostics, Basel, Switzerland) and sonicated on ice for 2030 s at level 23 (Sonicator XL2020, Heat Systems, Farmingdale, New York, USA)

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511 In the treatment of UC in children, patients may be prone to corticosteroid dependence, and infliximab can significantly relieve this dependence