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Pharmacol Ther 73(3):265280 Matthews JR, Wakasugi N, Virelizier JL, Yodoi J, Hay RT (1992) Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62

Wang Z, Chen M, Wang B, et al

A deficiency can result in severe neurological problems, including memory loss, depression, and significant nerve damage

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As a further example, corticotropin-releasing factor is secreted from the hypothalamus under stress and, together with neurotensin, can stimulate brain mast cells to release inflammatory and neurotoxic mediators that disrupt the BBB, stimulate microglia, and cause focal inflammation [527, 528]