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The response curves show that most participants were still losing weight at week 68, suggesting that longer treatment durations might produce even greater reductions

S.IeniM.FensterD

Pharmacological inhibition of USP14 enhances proteasomal degradation of several neurotoxic proteins, including tau, TDP14, and Ataxin-3 (Lee et al., 2010)

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However, even when high concentrations of NAC (50 g/mL) were added, the recovery rate was remarkably low compared to control cells, suggesting that cell growth inhibition and mitochondrial dysfunction are due not only to excessive ROS but also to other major pathways