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Issue published 27 November 2025 Abstract Objectives: Cisplatin (CDDP) therapy for glioblastoma (GBM) is linked with several limitations, which include poor penetration of the blood-brain barrier (BBB), systemic toxicity, and the development of drug resistance mechanisms implicating oxidative stress dysregulation and compromised apoptotic pathways

(Supplementary Table 1) containing both patients and healthy individuals and included: Alzheimers (GSE153712), Parkinsons (GSE111629), Multiple Sclerosis (GSE106648), and Fragile X Syndrome (GSE41273)

Binding at pH 7.4 was performed by single injections of 4000 nM FcRn-His over 2000 RU of immobilized NIP IgG1 variants at 25 C with a flow rate of 20 l/min

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Veljkovic AR, Nikolic RS, Kocic GM, et al