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Use of PK/PD biomarkers to define effective dose rangesBecause direct measurement of OSC in tissues may be challenging, surrogate markers (e.g., downstream redox- or thiol-modification biomarkers, mercapturic-acid conjugates, Nrf2 target-gene induction) should be used to calibrate individualized or population-level dosing

For example, thiamine suppressed lipid peroxidation and enhanced glutathione reductase activity in experimental cardiac hypertrophy in rats [95]

[DOI] [PubMed] [Google Scholar] 18.Laurent C.M., Green J.M., Bishop P.A., Sjkvist J., Schumacker R.E., Richardson M.T., Curtner-Smith M

gingivalis can bind to and acquire porphyrin molecules from Hb

doi: 10.1007/s00262-021-03013-3 8

Association of sleep deprivation and the risk of developing systemic lupus erythematosus among women