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15 Thus, a competition for selenium incorporation would be responsible for the decrease of the biosynthesis or activity of GPxs 1 and 3 leading to accumulation of H 2 O 2 that has been suggested to exert neurotoxic effects promoting oxidative stress and inflammation, which are critical factors of brain damage induced by cerebral ischemia

The absorbance at 340 nm will be determined through spectrophotometry, measuring the oxidation of NADPH to NADP+ for glutathione peroxidase and glutathione reductase

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human bloodbrain barrier endothelial cells

doi: 10.1016/j.celrep.2024.113688 71 SunTLiuBLiYWuJCaoYYangSet al

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