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doi: 10.1016/j.cellsig.2019.05.003

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126 USP20 stabilizes HMG-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis, and its inhibition reduces lipid levels and improves insulin sensitivity in preclinical models

Furthermore, AD and PD studies in mice found higher levels of antioxidant enzymes and a reduction of inflammatory markers in the brain, as well as improvement of behavioral impairment upon treatment with DMF (Table 1)

Subsequently, 500 L of 1.5 mM Sulfo-NHS-LC-biotin (APExBIO) in PBS (pH 8.0) was added to each well, and the plates were incubated at room temperature for 1 h