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INTRODUCTION Aging is associated with the systemic accumulation of damage, leading to a gradual loss of function, deterioration of organismal health, and an increased mortality rate 1

Thus, high bilirubin concentrations (100 M) resulted in early necrosis, but low-to-moderate doses (0.6625 M) primarily resulted in delayed apoptosis [22]

Moreover, in vitro experiments in astrocytes found this effect to be specifically induced by Efavirenzs primary metabolite but not the parent compound

However, compared with the PILO-treated hippocampal neurons, the NS8593 (10 M and 30 M) pretreatment combined with PILO treatment group (PILO + NS8593) significantly attenuated spontaneous APs (Fig

2 AggarwalA.GaurV.KumarA

Mathur M, Rizvi TA, Nayak NC