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In vivo experiments favor a ligand-dependent functional interaction between the AF-2 region in the ligand-binding domain with the NH 2 -terminal domain (113, 115)

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Mammalian Sirt1: Insights on its biological functions

Yousefi M, Khorshidian N, Hosseini H

These warts are usually flesh-colored, pink, or brownish, and are less noticeable individually but can be bothersome in groups