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Similarly, a study by Andreas Linkermann and colleagues demonstrated that mice with Fsp1 deficiency or GPX4 dysfunction exhibit increased sensitivity of renal tubular epithelial cells to ferroptosis during AKI [26]

Neuroinflammation and demyelination from the point of nitrosative stress as a new target for neuroprotection

216 SPLA2, another cardiomyokine, can increase hepatic triglyceride levels and affect VLDL secretion, contributing to nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH)

CagriSema, as of mid-2026, has completed its Phase 3a REDEFINE program but is not approved by the FDA, the EMA, or any other regulator, and its benefitrisk profile is still under review

Activated mTOR in lupus T cells is associated with several abnormalities including expansion of both T H 17 and CD3 + CD4 CD8 double negative T, as well as, contraction of Tregs (47, 48)

WM is currently funded by an Alfred Deakin Postdoctoral Research Fellowship and a Multiple Sclerosis Research Australia early-career fellowship