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This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

Proc Natl Acad Sci 102(43):1554515550

This may also lessen the extent to which astrocytes participate in peripheral immune cell recruitment and inflammation (Mecha et al., 2013)

Supplementary Table 2)

[Abstract]2025 Jun 18;18(6):969-977

Considering that SELENOP is also involved in the defense against oxidative damage and had a q-value that was second (Welch t-test q = 0.08, log(FC) = 0.66) to GPx3 in this group comparisons using an untargeted approach, we sought to monitor peptides of both of these proteins by targeted LC-MS/MS (Supplementary Fig