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Previous studies on PQQ have been focused on its activities as an antioxidant and redox modulator (7), a cardio- and neuro-protectant (23,24), and its radio-protective effects on the hemopoietic system (25)

On the other hand, greater intra-tumoral expression of VEGFR-3 may predict better response, while overexpression of VEGFR1 mainly indicates poor survival [192]