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The nephrotoxic mechanisms of pCS primarily involve inducing oxidative stress through activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, triggering inflammatory responses, and promoting renal fibrosis (124)

By integrating immunophenotypic, molecular, and functional data, IM enables earlier detection of relapse-associated immune dysfunction and supports preemptive, risk-adapted therapeutic interventions such as donor lymphocyte infusion or immunomodulatory strategies

5 It may also support collagen and elastin production, improve firmness and texture, and reduce inflammation that drives chronic skin conditions over time

Cytokine inhibitors, such as interleukin-6 (IL-6) inhibitors, may also be employed to target specific pro-inflammatory cytokines

3 Results and discussion 3.1 Main and derivative path analysis results By constructing a patent citation network and visualizing it using Pajek, the final main and derivative paths were identified (as shown in Figure 2)

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