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In Vitro 52 PinheiroJ.BatesD.DebRoyS.SarkarD.R Core Team (2009)

Curcumin enhanced the phagocytic activity by upregulating the expression of key phagocytic receptors in HD flies, while simultaneously suppressing the transcriptional expression of pro-inflammatory cytokines and anti-microbial peptides (Jain et al., 2025)

I think when you look at the fact that depression is so strongly correlated to altitude, I think thats a big signal and just the role of serotonin in handling hypoxia