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The OSK-KI mouse model, generated by knocking the Osaka mutation into the endogenous mouse APP gene, displayed APP expression levels similar to those of wild-type (WT) mice

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Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial