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Generally, severe AMS or HACE patients are advised to descend until their symptoms fully resolve, a process that typically involves a drop in altitude ranging from 300 to 1000 m

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J Geriatr Oncol 12(6):937-944, 2021

doi: 10.1016/S0197-2510(10)70232-1

A key finding from our work is that PTGIR signaling is sufficient to promote gene signatures of terminal exhaustion in the absence of chronic stimulation

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