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Martin ME, Byers BR, Olson MO, et al

In the central human study by Teichman and colleagues, a single subcutaneous dose produced a dose-dependent GH rise of 2- to 10-fold that persisted for at least 6 days, plus an IGF-1 rise of 1.5- to 3-fold over 9 to 11 days (Teichman et al., 2006)

doi:10.1111/j.1365-2222.2009.03302.x

As low levels of GH/IGF were also reported to delay puberty and reproduction in KO models, it seems feasible that this axis may be working by shifting a biological timer and delaying aging as a consequence, which may defer as well the arrival of age-related diseases (253)

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