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In obesity, autophagy markers such as LC3-II and autophagosome formation are elevated, accompanied by reduced mTORC1 activity, particularly in visceral depots

GLP-1 therapy with compounded semaglutide aims to leverage these effects

discovered that metformin inhibits the mitochondrial respiratory chain complex to prevent the electron transport from NADH to coenzyme Q, which somewhat lowers mitochondrial basal and maximal respiration and mildly limits ATP synthesis

Animal studies reveal that the inhibition of NOS alters memory formation and synaptic plasticity, causing amnesia [32,33]

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