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doi: 10.1172/JCI150377 30 SotznyFBlancoJCapelliECastro-MarreroJSteinerSMurovskaMet al

A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status

Metab Eng 5:277283

Rather than raising NAD+ systemically (as NMN or NR supplementation does), NNMT inhibition preserves NAD+ specifically in the tissue where metabolic dysfunction is most pronounced a precision approach that appeals to researchers studying tissue-specific metabolic regulation