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Description

Researchers suggest that future studies could explore NRF2 activity inhibitors applicable to humans or develop inhibitors targeting succinated GPX4 to induce ferroptosis in hereditary leiomyomatosis and renal cell cancer cells

When this vitamin is depleted by alcohol, it can interfere with immune function

A human mitochondrial ferritin encoded by an intronless gene

doi: 10.1038/nn.4476 63 Garca-ClosasM.MalatsN.SilvermanD.DosemeciM.KogevinasM.HeinD

Human osteoarthritic knee tissue obtained during joint-replacement surgery similarly responded to 15-PGDH inhibition in the lab by lowering expression of degradation markers and initiating new articular cartilage formation