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IM injection is generally preferred for larger injection volumes (typically 0.5-2mL) as muscle tissue accommodates greater fluid volumes with less discomfort than subcutaneous fat

In these cases, the itching may be a symptom of an underlying systemic condition

Thus, only about 50% of a rectal dose can be assumed to bypass the liver

Compared to VH-negative patients, PD patients with VH also exhibit lower bilateral FDG uptake in the occipital lobe, parietal cortex, right temporal lobe, and left cingulate, indicating a more severe brain metabolic decline and a higher risk of progression to dementia [43]

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(Andreja Petrovic), M.B.: Investigation