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In U20 APO/GSH/GS-PAP , this tryptophan residue is buried (accessible surface area (ASA) of 4 2 ), making the H-site quite deep (Supplementary Figure S6)

Proc Natl Acad Sci U S A 104:1556015565 Minamishima S, Bougaki M, Sips PY, De Yu J, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F (2009) Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3dependent mechanism in mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.OSullivan S.E

Expert Opin Drug Metab Toxicol 10:10611067

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Within the pulmonary milieu, ozone interaction with unsaturated fatty acids can yield lipid ozonation products, engendering lipid peroxidation, perturbed membrane permeability, and subsequent activation of inflammatory mediators [84]