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Int J Mol Sci (2019) 20(15):3775

Despite all these knowledge, there are documented drawbacks to fish oil use, which includes the presence of heavy metal contamination and antibiotics in fish sources (Sidhu, 2003), as well as smells and odors that are undesirable, issues with stability, high cost, and challenges in purifying because of the small levels of DHA and EPA fatty acids (Department of Forestry, Fisheries and the Environment (DFFE) et al., 2023)

Surface alterations such as PEGylation or biomimetic coatings can prevent protein adsorption and opsonization, effectively shielding the nanoparticles from recognition by the mononuclear phagocyte system (Rampado et al., 2020

These findings indicated that GPX4 overexpression decreased CaOX-induced ferroptosis in MTECs