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IRE1 facilitates serine palmitoyltransferase gene transcription via XBP1s, leading to the release of extracellular vesicles (EVs) from hepatocytes, thereby recruiting macrophages to foster hepatic inflammation and injury in NASH mice [41]

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These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body

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The Lancet Neurology , 22(5), 371373