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Kinetics and stoichiometry of fatty acid peroxidation

In addition to ferroptosis occurring in the tubules themselves, it has been shown that glomerular injury in patients with lupus nephritis triggers ferroptosis in tubules [134], therefore we hypothesized that the interaction between glomeruli and renal tubules plays an important role in the progression from AKI to CKD, and we await further studies on this topic with much anticipation

Together, these results indicate that acute oxidative stress causes metabolic adaptation through the oxidation of metabolic and mitochondrial proteins to amplify the production of reducing equivalents in the PPP, and potentially to minimise the production of endogenous ROS by inhibition of mitochondrial respiration