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Finally, we discuss potential future applications of novel therapies that target ROS spatiotemporal heterogeneity to prevent and manage HCC onset and progression

Although the levels of demethylation during the pre-implantation period are significant, a portion of DNA methylation will be kept during the reprogramming after fertilization, including the imprinted genes, which represent an inheritance from the paternal environment to the offspring phenotype (Jiang et al., 2018)

Third, they regulate the secretion of substances by the gut microbiota, sustain the integrity of the intestinal mucosal barrier structure, and indirectly change the diversity of the intestinal microbiota

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