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Dysfunction in mitochondria can lead to electron leakage in the electron transport chain, resulting in overproduction of ROS such as superoxide anions and hydrogen peroxide ( Endoplasmic reticulum oxidative stress: The endoplasmic reticulum (ER), responsible for protein synthesis and folding, is vulnerable to oxidative stress

Portal hypertension (PHT) is a complication of liver disease, involving macrophage activation and superoxide dismutase 3 (SOD3) in its pathogenesis

Metabolic response in the late 72 h reperfusion time suggests that neural cells accelerate glutamate metabolic recovery to substitute the deprivation induced by ischemic event and presumably compensate for the altered synthetic function of damaged neural cells

You can read more here: David Buak Gasser, Tobias A

Trends Biochem Sci (2014) 39:1918

88 Intravenous GSH is not directly taken up by hepatocytes but is degraded in the kidney