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Nanomed Res J

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Herein, we review outcomes from recent mouse models where gut permeability was altered by direct and indirect effects of manipulating mucosal barrier-associated proteins, to highlight the significance of mucosal permeability and the non-barrier-related roles of these proteins in regulating chronic mucosal inflammatory conditions

Malkin, 2008)

Moreover, considering the seno-antigens typically have important roles in intracellular signaling and regulation of immune responses, it remains to be investigated whether the inhibition of uPAR expressing cells could result in side effects such as impaired immune response, and their long-term effect on health status and lifespan remains poorly understood

In the present study, our results demonstrated that DP treatment significantly attenuated the levels of IL-6 in the nerve tissue, concomitantly reducing other pro-inflammatory cytokines, such as IL-1 and IL-13