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doi:10.1016/S0140-6736(88)91898-3

It turns out that taking too much B12 might trigger subtle inflammation in kidney tissue that standard blood tests dont pick up

Volume differences Brand-name pens deliver a fixed dose in a fixed volume that is optimized for subcutaneous comfort

A high serum value can still carry clinical meaning even though there is no established upper intake limit for oral B12

MIC B12 is generally safe when administered by licensed providers, but avoid if you have liver disease, kidney dysfunction, or bleeding disorders