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16-week cycle: 1 vial Concentration: ~3.33 mg/mL Dose basis: total blend, once weekly Insulin Syringes (U-100, 1 mL) Per injection: 1 syringe 16 weeks (once weekly): ~16 syringes Use a U-100 1 mL syringe per injection Bacteriostatic Water (10 mL bottles) Use ~3.0 mL to reconstitute the single 10 mg blend vial

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This is particularly concerning for older adults, postmenopausal women, and anyone with existing osteoporosis risk factors

doi: 10.1089/neu.1999.16.69

Central nervous system effects on appetite appear to complement GLP-1 signaling through distinct neurological pathways