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J Investig Allergol Clin Immunol 32(1):6668

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Initially, the mechanisms of action of this enzyme were considered paradoxical because CD38 is predominantly localized on the cell surface, yet its final products are utilized within cytoplasmic compartments

Subsequent research in Japan found that Lactobacillus helveticus -Fermented Milk Whey (LHMW) could inhibit melanin synthesis (Ikarashi et al., 2020)