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Elevated production of ROS in C9orf72-associated ALS is also associated with abnormalities in mitochondrial function and neuroinflammation (Briehl et al., 80 DPRs interact with Atp5a1, which compromises mitochondrial functions in mice due to increased ROS production (Choi et al., 2019)

Doseresponse analysis further indicated a statistically significant augmentation in mortality risk at doses above 150 IU/day (27)

Siraki AG (2021) The many roles of myeloperoxidase: from inflammation and immunity to biomarkers, drug metabolism and drug discovery

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and $\alpha$-synuclein

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In a randomized, placebo-controlled phase 1 clinical trial, 14-day treatment with TLC-2716 was well tolerated (primary endpoints) and resulted in placebo-adjusted reductions up to 38.5% in plasma TG and 61% in postprandial remnant cholesterol (secondary endpoints)