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With p53 influence, aspartate and arginine uptake is increased, with the latter activating mTORC1 to promote tumor growth

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

doi: 10.7324/japs.2019.91008 11 ChenYYanYLiuHQiuFLiangCLZhangQet al

doi: 10.3389/fphar.2016.00163 413

Notably, the hydroxyl group at the C4 position of the tetrahydropyran ring of substrate 7 also stabilizes the GSH-thiolate through an additional hydrogen bond (Extended Data Fig