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[DOI] [PubMed] [Google Scholar] Nistala R, Whaley-Connell A, Sowers JR

Accreditation Statement Pharmacists and Pharmacy Technicians are eligible to participate in this knowledge-based activity and will receive up to 1.0 CE Hours (or 0.1 CEUs) for completing the activity ACPE UAN 0009-0000-23-044-H05-P , passing the quiz with a grade of 70% or better, and completing an online evaluation

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Mechanism of Action: Octopamine replaces norepinephrine in sympathetic neurons with chronic use of monoamine oxidase inhibitors Dopamine beta-hydroxylase converts tyramine to octopamine Octopamine can be taken up into storage vesicles in nerve terminals, and then be released by nerve stimulation Octopamine exerts only a small effect on postsynaptic receptors compared to norepinephrine (hence the designation false transmitter) Notes: Octopamine typically exists in only trace amounts in the mammalian CNS, but accumulates when MAO is inhibited (e.g

About 41.2% of patients in the SZC group responded to treatment compared with 1% of the 99 patients receiving placebo